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Gewählte Publikation:

Publikationstyp: Zeitschriftenaufsatz
Dokumentart: Originalarbeit

Publikationsjahr: 2014

AutorInnen: Wagener, K; Grunert, T; Prunner, I; Ehling-Schulz, M; Drillich, M

Titel: Dynamics of uterine infections with Escherichia coli, Streptococcus uberis and Trueperella pyogenes in post-partum dairy cows and their association with clinical endometritis.

Quelle: Vet J. 2014; 202(3):527-532



Autor/innen der Vetmeduni Vienna:

Drillich Marc
Ehling-Schulz Monika
Grunert Tom
Prunner Isabella
Wagener Karen

Beteiligte Vetmed-Organisationseinheiten
Institut für Mikrobiologie, Abteilung für Funktionelle Mikrobiologie
Universitätsklinik für Wiederkäuer, Bestandsbetreuung bei Wiederkäuern


Ausgezeichnet mit:

  • The Veterinary Journal’s 2014 Junior Scientist Prize.

  • Abstract:
    The diversity and dynamics of the uterine microbiota of dairy cows are poorly understood although it is becoming increasingly evident that they play a crucial role in the development of metritis and endometritis. Fourier-transform infrared (FTIR) spectroscopy was used to monitor the bovine microbiota of 40 cows on the day of calving and days 3, 9, 15, and 21 after parturition, and to investigate the associations of selected species with clinical endometritis (CE). Trueperella pyogenes (43.5%), Escherichia coli (21.5%), Bacillus spp. (21.0%) and Streptococcus uberis (18.5%) were the most frequently isolated microbes. Analyses of different sampling time points revealed that the presence of S. uberis on day 3 increased the risk of subsequent T. pyogenes infection on day 9 (odds ratio [OR] = 5.1, 95% confidence interval [CI] = 1.2-22.6). T. pyogenes infection (OR = 36.0, 95% CI = 3.8-343.2) and retained fetal membranes (RFM) (OR = 12.4, 95%CI = 1.4-112.7) were significant risk factors for CE. Cows with S. uberis on day 3 tended to have greater odds of CE than S. uberis-negative cows (OR = 7.1, 95% CI = 0.9-55.6). Chemometric analysis revealed significant differences in the metabolic profile of S. uberis strains isolated from cows with different vaginal discharge scores. This is the first study showing the association of specific S. uberis subtypes with the uterine health status of post-partum dairy cows. The study demonstrates that uterine clearance is a highly dynamic process, during which time bacteria show distinct patterns of progression, and provides information about interactions between bacterial species involved in the occurrence of CE.

    Keywords Pubmed: Actinomycetales Infections/epidemiology
    Actinomycetales Infections/immunology
    Actinomycetales Infections/microbiology
    Actinomycetales Infections/veterinary
    Animals
    Arcanobacterium/isolation & purification
    Cattle
    Cattle Diseases/epidemiology*
    Cattle Diseases/immunology
    Cattle Diseases/microbiology*
    Corynebacterium Infections/epidemiology
    Corynebacterium Infections/immunology
    Corynebacterium Infections/microbiology
    Corynebacterium Infections/veterinary*
    Corynebacterium pyogenes/isolation & purification
    Endometritis/epidemiology
    Endometritis/immunology
    Endometritis/microbiology
    Endometritis/veterinary*
    Escherichia coli/isolation & purification
    Escherichia coli Infections/epidemiology
    Escherichia coli Infections/immunology
    Escherichia coli Infections/microbiology
    Escherichia coli Infections/veterinary*
    Female
    Germany/epidemiology
    Polymerase Chain Reaction
    Postpartum Period
    Prevalence
    Prospective Studies
    Spectroscopy, Fourier Transform Infrared/veterinary
    Streptococcal Infections/epidemiology
    Streptococcal Infections/immunology
    Streptococcal Infections/microbiology
    Streptococcal Infections/veterinary*
    Streptococcus/isolation & purification
    Uterine Diseases/epidemiology
    Uterine Diseases/immunology
    Uterine Diseases/microbiology
    Uterine Diseases/veterinary*


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