Veterinärmedizinische Universität Wien Forschungsinformationssystem VetDoc

Grafischer Link zur Startseite der Vetmeduni Vienna

Gewählte Publikation:

Publikationstyp: Zeitschriftenaufsatz
Dokumenttyp: Übersichtsarbeit

Jahr: 2014

AutorInnen: Ye, X; Shokrollahi, K; Rozen, WM; Conyers, R; Wright, P; Kenner, L; Turner, SD; Whitaker, IS

Titel: Anaplastic large cell lymphoma (ALCL) and breast implants: breaking down the evidence.

Quelle: Mutat Res Rev Mutat Res. 2014; 762:123-132



Autor/innen der Vetmeduni Vienna:

Kenner Lukas

Beteiligte Vetmed-Organisationseinheiten
Institut für Pathologie, Abteilung für Labortierpathologie


Abstract:
Systemic anaplastic large cell lymphoma (ALCL) is a distinct disease classification provisionally sub-divided into ALCL, Anaplastic Lymphoma Kinase (ALK)(+) and ALCL, ALK(-) entities. More recently, another category of ALCL has been increasingly reported in the literature and is associated with the presence of breast implants. A comprehensive review of the 71 reported cases of breast implant associated ALCL (iALCL) is presented indicating the apparent risk factors and main characteristics of this rare cancer. The average patient is 50 years of age and most cases present in the capsule surrounding the implant as part of the periprosthetic fluid or the capsule itself on average at 10 years post-surgery suggesting that iALCL is a late complication. The absolute risk is low ranging from 1:500,000 to 1:3,000,000 patients with breast implants per year. The majority of cases are ALK-negative, yet are associated with silicone-coated implants suggestive of the mechanism of tumorigenesis which is discussed in relation to chronic inflammation, immunogenicity of the implants and sub-clinical infection. In particular, capsulotomy alone seems to be sufficient for the treatment of many cases suggesting the implants provide the biological stimulus whereas others require further treatment including chemo- and radiotherapy although reported cases remain too low to recommend a therapeutic approach. However, CD30-based therapeutics might be a future option.

Keywords Pubmed: Animals
Breast Implantation/adverse effects*
Female
Humans
Lymphoma, Large-Cell, Anaplastic/epidemiology
Lymphoma, Large-Cell, Anaplastic/etiology*
Lymphoma, Large-Cell, Anaplastic/therapy
Middle Aged
Receptor Protein-Tyrosine Kinases/genetics*
Risk Factors
Silicone Gels/adverse effects


© Veterinärmedizinische Universität Wien Hilfe und DownloadsErklärung zur Barrierefreiheit