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Gewählte Publikation:

Publikationstyp: Zeitschriftenaufsatz
Dokumenttyp: Originalarbeit

Jahr: 2015

AutorInnen: Nivarthi, H; Prchal-Murphy, M; Swoboda, A; Hager, M; Schlederer, M; Kenner, L; Tuckermann, J; Sexl, V; Moriggl, R; Ermakova, O

Titel: Stat5 gene dosage in T cells modulates CD8+ T-cell homeostasis and attenuates contact hypersensitivity response in mice.

Quelle: Allergy. 2015; 70(1):67-79



Autor/innen der Vetmeduni Vienna:

Kenner Lukas
Moriggl Richard
Prchal-Murphy Michaela
Sexl Veronika

Beteiligte Vetmed-Organisationseinheiten
Institut für Pharmakologie und Toxikologie


Abstract:
Contact hypersensitivity assay (CHS) faithfully models human allergies. The Stat5 transcription factors are essential for both lymphocyte development and acute immune responses. Although consequences of Stat5 ablation and transgenic overexpression for the lymphocyte development and functions have been extensively studied, the role of Stat5 gene dosage in contact allergies has not been addressed.

Keywords Pubmed: Animals
CD8-Positive T-Lymphocytes/immunology*
CD8-Positive T-Lymphocytes/metabolism*
Dermatitis, Contact/blood
Dermatitis, Contact/genetics*
Dermatitis, Contact/immunology*
Disease Models, Animal
Gene Dosage*
Germ Cells/metabolism
Haploinsufficiency
Homeostasis*
Leukocyte Count
Lymphocyte Activation/genetics
Lymphocyte Activation/immunology
Lymphocyte Count
Mice
Mice, Transgenic
STAT5 Transcription Factor/genetics*
Thymus Gland/immunology
Thymus Gland/metabolism


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