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Gewählte Publikation:

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Publikationstyp: Zeitschriftenaufsatz
Dokumenttyp: Originalarbeit

Jahr: 2015

AutorInnen: Jensen-Jarolim, E; Fazekas, J; Singer, J; Hofstetter, G; Oida, K; Matsuda, H; Tanaka, A

Titel: Crosstalk of carcinoembryonic antigen and transforming growth factor-β via their receptors: comparing human and canine cancer.

Quelle: Cancer Immunol Immunother. 2015; 64(5):531-537

Autor/innen der Vetmeduni Vienna:

Hofstetter Gerlinde
Jensen-Jarolim Erika
Singer Judit

Beteiligte Vetmed-Organisationseinheiten
Messerli Forschungsinstitut, Abteilung für Komparative Medizin

There is accumulating evidence that the transforming growth factor beta (TGF-β) and nuclear factor kappa-B (NFκB) pathways are tightly connected and play a key role in malignant transformation in cancer. Immune infiltration by regulatory T- and B-lymphocytes (Tregs, Bregs) has recently gained increased attention for being an important source of TGF-β. There is a plethora of studies examining the pro-tumorigenic functions of carcinoembryonic antigen (CEA), but its receptor CEAR is far less studied. So far, there is a single connecting report that TGF-β also may signal through CEAR. The crosstalk between cancer tissues is further complicated by the expression of CEAR and TGF-β receptors in stromal cells, and implications of TGF-β in epithelial-mesenchymal transition. Furthermore, tumor-infiltrating Tregs and Bregs may directly instruct cancer cells by secreting TGF-β binding to their CEAR. Therefore, both TGF-β and CEA may act synergistically in breast cancer and cause disease progression, and NFκB could be a common crossing point between their signaling. CEAR, TGF-β1-3, TGF-β-R types I-III and NFκB class I and II molecules have an outstanding human-canine sequence identity, and only a canine CEA homolog has not yet been identified. For these reasons, the dog may be a valid translational model patient for investigating the crosstalk of the interconnected CEA and TGF-β networks.

Keywords Pubmed: Animals
B-Lymphocytes, Regulatory/immunology
Carcinoembryonic Antigen/metabolism*
Dog Diseases/immunology*
Epithelial-Mesenchymal Transition
I-kappa B Kinase/metabolism
NF-kappa B/metabolism
Protein Binding
Receptors, Cell Surface/genetics
Receptors, Cell Surface/metabolism*
Receptors, Transforming Growth Factor beta/metabolism*
T-Lymphocytes, Regulatory/immunology
Transforming Growth Factor beta/metabolism*

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