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Gewählte Publikation:

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Publikationstyp: Zeitschriftenaufsatz
Dokumenttyp: Originalarbeit

Jahr: 2015

AutorInnen: Krunic, M; Ertl, R; Hagen, B; Sedlazeck, FJ; Hofmann-Lehmann, R; von Haeseler, A; Klein, D

Titel: Decreased expression of endogenous feline leukemia virus in cat lymphomas: a case control study.

Quelle: BMC Vet Res. 2015; 11:90



Autor/innen der Vetmeduni Vienna:

Ertl Reinhard
Klein Dieter

Beteiligte Vetmed-Organisationseinheiten
VetCore


Abstract:
Cats infected with exogenous feline leukemia virus (exFeLV) have a higher chance of lymphoma development than uninfected cats. Furthermore, an increased exFeLV transcription has been detected in lymphomas compared to non-malignant tissues. The possible mechanisms of lymphoma development by exFeLV are insertional mutagenesis or persistent stimulation of host immune cells by viral antigens, bringing them at risk for malignant transformation. Vaccination of cats against exFeLV has in recent years decreased the overall infection rate in most countries. Nevertheless, an increasing number of lymphomas have been diagnosed among exFeLV-negative cats. Endogenous feline leukemia virus (enFeLV) is another retrovirus for which transcription has been observed in cat lymphomas. EnFeLV provirus elements are present in the germline of various cat species and share a high sequence similarity with exFeLV but, due to mutations, are incapable of producing infectious viral particles. However, recombination between exFeLV and enFeLV could produce infectious particles.

Keywords Pubmed: Animals
Base Sequence
Case-Control Studies
Cat Diseases/pathology
Cat Diseases/virology*
Cats
Female
Gene Expression Regulation, Viral/physiology*
Leukemia Virus, Feline/genetics
Leukemia Virus, Feline/metabolism*
Lymphoma/veterinary*
Lymphoma/virology
Male
RNA, Viral/genetics
RNA, Viral/metabolism
Retroviridae Infections/veterinary*
Retroviridae Infections/virology
Reverse Transcriptase Polymerase Chain Reaction
Tumor Virus Infections/veterinary*
Tumor Virus Infections/virology


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