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Gewählte Publikation:

Publikationstyp: Zeitschriftenaufsatz
Dokumenttyp: Originalarbeit

Jahr: 2015

AutorInnen: Paudel, S; Hess, C; Wernsdorf, P; Käser, T; Meitz, S; Jensen-Jarolim, E; Hess, M; Liebhart, D

Titel: The systemic multiplication of Gallibacterium anatis in experimentally infected chickens is promoted by immunosuppressive drugs which have a less specific effect on the depletion of leukocytes.

Quelle: Vet Immunol Immunopathol. 2015; 166(1-2):22-32

Autor/innen der Vetmeduni Vienna:

Hess Claudia
Hess Michael
Jensen-Jarolim Erika
Käser Tobias
Liebhart Dieter
Paudel Surya
Wernsdorf Patricia

Beteiligte Vetmed-Organisationseinheiten
Messerli Forschungsinstitut, Abteilung für Komparative Medizin
Institut für Immunologie
Universitätsklinik für Geflügel und Fische, Klinische Abteilung für Geflügelmedizin

The progression of Gallibacterium anatis infection in immunosuppressed versus immunocompetent chickens was investigated. Before experimental infection, birds were treated with corticosterone for general immunosuppression, or 5-fluorouracil, cyclosporine-A, cyclophosphamide for depletion of specific leukocyte populations. Necropsy and sampling were performed at 0, 3, 7, 10 and 28 days post infection. The used drugs did not cause selected depletion of B cells, T cells, heterophils and monocytes/macrophages, as determined by quantification of leukocytes in blood and lymphoid organs using different technologies. Bacterial re-isolation and counts of colony forming units (CFU) showed that G. anatis colonization pattern in various organs, and the numbers of bacteria in trachea were not affected by immunosuppression. However, the treatments acutely increased CFU counts derived from the spleen, which demonstrates that chemically induced immunosuppression intensifies systemic multiplication of G. anatis in chickens.

Keywords Pubmed: Animals
Bacterial Load
Immunosuppressive Agents/pharmacology*
Leukocyte Count
Leukocytes/drug effects*
Pasteurellaceae Infections/veterinary*
Poultry Diseases/immunology*
Poultry Diseases/microbiology

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