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Gewählte Publikation:

Publikationstyp: Zeitschriftenaufsatz
Dokumentart: Originalarbeit

Publikationsjahr: 2013

AutorInnen: Wressnigg, N; Pöllabauer, EM; Aichinger, G; Portsmouth, D; Löw-Baselli, A; Fritsch, S; Livey, I; Crowe, BA; Schwendinger, M; Brühl, P; Pilz, A; Dvorak, T; Singer, J; Firth, C; Luft, B; Schmitt, B; Zeitlinger, M; Müller, M; Kollaritsch, H; Paulke-Korinek, M; Esen, M; Kremsner, PG; Ehrlich, HJ; Barrett, PN

Titel: Safety and immunogenicity of a novel multivalent OspA vaccine against Lyme borreliosis in healthy adults: a double-blind, randomised, dose-escalation phase 1/2 trial.

Quelle: Lancet Infect Dis (13), 8 680-689.



Autor/innen der Vetmeduni Vienna:

Firth Clair

Diese Publikation wurde nicht im Namen der Vetmeduni Vienna erstellt und ist deshalb ausschließlich der persönlichen Publikationsliste des/der Autors/Autorin zugeordnet!


Abstract:
Lyme borreliosis is caused by Borrelia burgdorferi sensu stricto in the USA and by several Borrelia species in Europe and Asia, but no human vaccine is available. We investigated the safety and immunogenicity of adjuvanted and non-adjuvanted vaccines containing protective epitopes from Borrelia species outer surface protein A (OspA) serotypes in healthy adults.

Keywords Pubmed: Adjuvants, Immunologic/adverse effects*
Adult
Antigens, Surface/adverse effects*
Antigens, Surface/immunology*
Bacterial Outer Membrane Proteins/adverse effects*
Bacterial Outer Membrane Proteins/immunology*
Bacterial Vaccines/adverse effects*
Bacterial Vaccines/immunology*
Borrelia burgdorferi/immunology*
Double-Blind Method
Female
Headache/chemically induced
Humans
Immunoglobulin G/blood
Lipoproteins/adverse effects*
Lipoproteins/immunology*
Lyme Disease Vaccines/adverse effects*
Lyme Disease Vaccines/immunology*
Male
Middle Aged
Pain/chemically induced
Young Adult


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