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Publikationstyp: Zeitschriftenaufsatz
Dokumenttyp: Übersichtsarbeit

Jahr: 2016

AutorInnen: Jensen-Jarolim, E; Pacios, LF; Bianchini, R; Hofstetter, G; Roth-Walter, F

Titel: Structural similarities of human and mammalian lipocalins, and their function in innate immunity and allergy.

Quelle: Allergy. 2016; 71(3):286-294

Autor/innen der Vetmeduni Vienna:

Bianchini Rodolfo
Hofstetter Gerlinde
Jensen-Jarolim Erika
Roth-Walter Franziska

Beteiligte Vetmed-Organisationseinheiten
Messerli Forschungsinstitut, Abteilung für Komparative Medizin

Owners and their domestic animals via skin shedding and secretions, mutually exchange microbiomes, potential pathogens and innate immune molecules. Among the latter especially lipocalins are multifaceted: they may have an immunomodulatory function and, furthermore, they represent one of the most important animal allergen families. The amino acid identities, as well as their structures by superposition modeling were compared among human lipocalins, hLCN1 and hLCN2, and most important animal lipocalin allergens, such as Can f 1, Can f 2 and Can f 4 from dog, Fel d 4 from cats, Bos d 5 from cow's milk, Equ c 1 from horses, and Mus m 1 from mice, all of them representing major allergens. The β-barrel fold with a central molecular pocket is similar among human and animal lipocalins. Thereby, lipocalins are able to transport a variety of biological ligands in their highly conserved calyx-like cavity, among them siderophores with the strongest known capability to complex iron (Fe(3+) ). Levels of human lipocalins are elevated in nonallergic inflammation and cancer, associated with innate immunoregulatory functions that critically depend on ligand load. Accordingly, deficient loading of lipocalin allergens establishes their capacity to induce Th2 hypersensitivity. Our similarity analysis of human and mammalian lipocalins highlights their function in innate immunity and allergy. © 2015 The Authors. Allergy Published by John Wiley & Sons Ltd.

Keywords Pubmed: Allergenschemistryimmunologymetabolism
Immune Tolerance
Immunity, Innate
Immunoglobulin Eimmunology
Protein Conformation
Structure-Activity Relationship
Th2 Cellsimmunologymetabolism

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