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Gewählte Publikation:

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Publikationstyp: Zeitschriftenaufsatz
Dokumenttyp: Originalarbeit

Jahr: 2016

AutorInnen: Gebhard, C; Fuchs-Baumgartinger, A; Razzazi-Fazeli, E; Miller, I; Walter, I

Titel: Distribution and activity levels of matrix metalloproteinase 2 and 9 in canine and feline osteosarcoma.

Quelle: Can J Vet Res. 2016; 80(1):66-73

Entstanden unter Nutzung der Ressourcen von
VetCore (VetBiobank);
VetCore (Proteomics);

Autor/innen der Vetmeduni Vienna:

Fuchs-Baumgartinger Andrea
Miller Ingrid
Razzazi-Fazeli Ebrahim
Walter Ingrid

Beteiligte Vetmed-Organisationseinheiten
Institut für Medizinische Biochemie
Institut für Morphologie
Institut für Pathologie
VetCore


Zugehörige(s) Projekt(e): Molekulare Biomarker des primären Osteosarkoms von Hund und Katze


Abstract:
Overexpression of matrix metalloproteinases (MMPs) has been associated with increased tumor aggressiveness and metastasis dissemination. We investigated whether the contrasting metastatic behavior of feline and canine osteosarcoma is related to levels and activities of MMP2 and MMP9. Zymography and immunohistochemistry were used to determine expression levels of MMP2 and MMP9 in canine and feline osteosarcoma. Using immunohistochemistry, increased MMP9 levels were identified in most canine osteosarcomas, whereas cat samples more often displayed moderate levels. High levels of pro-MMP9, pro-MMP2, and active MMP2 were detected by gelatin zymography in both species, with significantly higher values for active MMP2 in canine osteosarcoma. These findings indicate that MMP2 is probably involved in canine and feline osteosarcoma and their expression and activity could be associated with the different metastatic behavior of canine and feline osteosarcoma.

Keywords Pubmed: Animals
Bone Neoplasmsenzymologymetabolismveterinary
Cat Diseasesmetabolism
Cats
Dog Diseasesmetabolism
Dogs
Female
Gene Expression Regulation, Neoplasticphysiology
Male
Matrix Metalloproteinase 2geneticsmetabolism
Matrix Metalloproteinase 9geneticsmetabolism
Osteosarcomaenzymologymetabolismveterinary

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