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Gewählte Publikation:

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Publikationstyp: Zeitschriftenaufsatz
Dokumenttyp: Originalarbeit

Jahr: 2016

AutorInnen: Manzano-Szalai, K; Pali-Schöll, I; Krishnamurthy, D; Stremnitzer, C; Flaschberger, I; Jensen-Jarolim, E

Titel: Anaphylaxis Imaging: Non-Invasive Measurement of Surface Body Temperature and Physical Activity in Small Animals.

Quelle: PLoS One. 2016; 11(3):e0150819



Autor/innen der Vetmeduni Vienna:

Jensen-Jarolim Erika
Pali Isabella
Szalai Krisztina

Beteiligte Vetmed-Organisationseinheiten
Messerli Forschungsinstitut, Abteilung für Komparative Medizin


Daten sind in Figshare abgelegt. | DataLink: http://dx.doi.org/10.6084/m9.figshare.2804578


Abstract:
In highly sensitized patients, the encounter with a specific allergen from food, insect stings or medications may rapidly induce systemic anaphylaxis with potentially lethal symptoms. Countless animal models of anaphylaxis, most often in BALB/c mice, were established to understand the pathophysiology and to prove the safety of different treatments. The most common symptoms during anaphylactic shock are drop of body temperature and reduced physical activity. To refine, improve and objectify the currently applied manual monitoring methods, we developed an imaging method for the automated, non-invasive measurement of the whole-body surface temperature and, at the same time, of the horizontal and vertical movement activity of small animals. We tested the anaphylaxis imaging in three in vivo allergy mouse models for i) milk allergy, ii) peanut allergy and iii) egg allergy. These proof-of-principle experiments suggest that the imaging technology represents a reliable non-invasive method for the objective monitoring of small animals during anaphylaxis over time. We propose that the method will be useful for monitoring diseases associated with both, changes in body temperature and in physical behaviour.

Keywords Pubmed: Anaphylaxisphysiopathology
Animals
Body Temperature
Diagnostic Imagingmethods
Disease Models, Animal
Food Hypersensitivityphysiopathology
Mice
Mice, Inbred BALB C
Motor Activity

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