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Gewählte Publikation:

Publikationstyp: Zeitschriftenaufsatz
Dokumentart: Originalarbeit

Publikationsjahr: 2016

AutorInnen: Gabner, S; Hlavaty, J; Velde, K; Renner, M; Jenner, F; Egerbacher, M

Titel: Inflammation-induced transgene expression in genetically engineered equine mesenchymal stem cells.

Quelle: J Gene Med. 2016; 18(8):154-164



Autor/innen der Vetmeduni Vienna:

Egerbacher Monika
Gabner Simone
Hlavaty Juraj
Jenner Florien
Velde Karsten

Beteiligte Vetmed-Organisationseinheiten
Institut für Topographische Anatomie
Universitätsklinik für Pferde, Klinische Abteilung für Pferdechirurgie


Abstract:
Osteoarthritis, a chronic and progressive degenerative joint disorder, ranks amongst the top five causes of disability. Given the high incidence, associated socioeconomic costs and the absence of effective disease-modifying therapies of osteoarthritis, cell-based treatments offer a promising new approach. Owing to their paracrine, differentiation and self-renewal abilities, mesenchymal stem cells (MSCs) have great potential for regenerative medicine, which might be further enhanced by targeted gene therapy. Hence, the development of systems allowing transgene expression, particularly when regulated by natural disease-dependent occuring substances, is of high interest.


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