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Publikationstyp: Zeitschriftenaufsatz
Dokumenttyp: Originalarbeit

Jahr: 2016

AutorInnen: Pencik, J; Pham, HT; Schmoellerl, J; Javaheri, T; Schlederer, M; Culig, Z; Merkel, O; Moriggl, R; Grebien, F; Kenner, L

Titel: JAK-STAT signaling in cancer: From cytokines to non-coding genome.

Quelle: Cytokine. 2016; 87:26-36



Autor/innen der Vetmeduni Vienna:

Grebien Florian
Javaheri Tahereh
Kenner Lukas
Moriggl Richard
Pham Ha

Beteiligte Vetmed-Organisationseinheiten
Institut für Tierzucht und Genetik, Abteilung für Funktionelle Krebsgenomik
Institut für Pathologie, Abteilung für Labortierpathologie


Abstract:
In the past decades, studies of the Janus kinases (JAKs) and signal transducers and activators of transcription (STATs) signaling have uncovered highly conserved programs linking cytokine signaling to the regulation of essential cellular mechanisms such as proliferation, invasion, survival, inflammation and immunity. Inhibitors of the JAK/STAT pathway are used for treatment of autoimmune diseases, such as rheumatoid arthritis or psoriasis. Aberrant JAK/STAT signaling has been identified to contribute to cancer progression and metastatic development. Targeting of JAK/STAT pathway is currently one of the most promising therapeutic strategies in prostate cancer (PCa), hematopoietic malignancies and sarcomas. Notably, newly identified regulators of JAK/STAT signaling, the non-coding RNAs transcripts and their role as important targets and potential clinical biomarkers are highlighted in this review. In addition to the established role of the JAK/STAT signaling pathway in traditional cytokine signaling the non-coding RNAs add yet another layer of hidden regulation and function. Understanding the crosstalk of non-coding RNA with JAK/STAT signaling in cancer is of critical importance and may result in better patient stratification not only in terms of prognosis but also in the context of therapy.Copyright © 2016 Elsevier Ltd. All rights reserved.

Keywords Pubmed: Animals
Cytokinesmetabolism
Genome
Humans
Janus Kinasesmetabolism
Male
Mice
Neoplasmsmetabolismtherapy
Prostatic Neoplasmsmetabolismtherapy
RNA, Untranslatedmetabolism
STAT Transcription Factorsmetabolism
Sarcomametabolismtherapy
Signal Transduction

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