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Gewählte Publikation:

Publikationstyp: Zeitschriftenaufsatz
Dokumenttyp: Originalarbeit

Jahr: 2016

AutorInnen: Zaccaroni, M; Seta, DD; Farabollini, F; Fusani, L; Dessì-Fulgheri, F

Titel: Developmental Exposure to Very Low Levels of Ethynilestradiol Affects Anxiety in a Novelty Place Preference Test of Juvenile Rats.

Quelle: Neurotox Res. 2016; 30(4):553-562

Autor/innen der Vetmeduni Vienna:

Fusani Leonida

Beteiligte Vetmed-Organisationseinheiten
Konrad Lorenz Institut für Vergleichende Verhaltensforschung, Abteilung für Ornithologie

Ethinylestradiol (EE2), a synthetic mimic of 17β-estradiol, is widespread in the environment because of its use as a contraceptive. In mammals, recent research highlighted behavioral, physiological, and morphological effects of exposition to EE2 (this xenoestrogen). We studied if developmental exposure to environmental-like, low doses of EE2 affects measures of anxiety in Sprague-Dawley rats. We treated male and female rats with two doses of EE2 (4 and 400 ng/kg/day) either from GD 5 through PND 32 or from PND 1 through 21. Effects on anxiety were tested by novel place preference tests. In males and females treated from GD 5 through PND 32, a significant reduction of the time passed in the novel environment was observed. The decrease of the time spent in the novel compartment and the increase in the number of transitions between familiar and novel compartments indicate increased levels of anxiety in the EE2-treated subjects. These studies suggest that exposure to very low doses of EE2 during development can affect key behavioral traits that are modulated by anxiety.

Keywords Pubmed: Analysis of Variance
Anxietychemically induced
Disease Models, Animal
Dose-Response Relationship, Drug
Environmental Exposure
Ethinyl Estradioltoxicity
Motor Activitydrug effects
Prenatal Exposure Delayed Effects
Rats, Sprague-Dawley
Recognition, Psychology
Spatial Behaviordrug effects

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