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Gewählte Publikation:

Publikationstyp: Zeitschriftenaufsatz
Dokumenttyp: Originalarbeit

Jahr: 2017

AutorInnen: Marasco, V; Stier, A; Boner, W; Griffiths, K; Heidinger, B; Monaghan, P

Titel: Environmental conditions can modulate the links among oxidative stress, age, and longevity.

Quelle: Mech Ageing Dev. 2017; 164:100-107

Autor/innen der Vetmeduni Vienna:

Marasco Valeria

Diese Publikation wurde nicht im Namen der Vetmeduni Vienna erstellt und ist deshalb ausschließlich der persönlichen Publikationsliste des/der Autors/Autorin zugeordnet!

Understanding the links between environmental conditions and longevity remains a major focus in biological research. We examined within-individual changes between early- and mid-adulthood in the circulating levels of four oxidative stress markers linked to ageing, using zebra finches (Taeniopygia guttata): a DNA damage product (8-hydroxy-2'-deoxyguanosine; 8-OHdG), protein carbonyls (PC), non-enzymatic antioxidant capacity (OXY), and superoxide dismutase activity (SOD). We further examined whether such within-individual changes differed among birds living under control (ad lib food) or more challenging environmental conditions (unpredictable food availability), having previously found that the latter increased corticosterone levels when food was absent but improved survival over a three year period. Our key findings were: (i) 8-OHdG and PC increased with age in both environments, with a higher increase in 8-OHdG in the challenging environment; (ii) SOD increased with age in the controls but not in the challenged birds, while the opposite was true for OXY; (iii) control birds with high levels of 8-OHdG died at a younger age, but this was not the case in challenged birds. Our data clearly show that while exposure to the potentially damaging effects of oxidative stress increases with age, environmental conditions can modulate the pace of this age-related change.Copyright © 2017 Elsevier B.V. All rights reserved.

Keywords Pubmed: 8-Hydroxy-2'-Deoxyguanosine
Avian Proteinsblood
DNA Damage
Deoxyguanosineanalogs & derivativesblood
Oxidative Stressphysiology
Superoxide Dismutaseblood

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