Valent, P; Akin, C; Arock, M; Bock, C; George, TI; Galli, SJ; Gotlib, J; Haferlach, T; Hoermann, G; Hermine, O; Jäger, U; Kenner, L; Kreipe, H; Majeti, R; Metcalfe, DD; Orfao, A; Reiter, A; Sperr, WR; Staber, PB; Sotlar, K; Schiffer, C; Superti-Furga, G; Horny, HP
Proposed Terminology and Classification of Pre-Malignant Neoplastic Conditions: A Consensus Proposal.
EBioMedicine. 2017; 26:17-24
Autor/innen der Vetmeduni Vienna:
Institut für Pathologie, Abteilung für Labortierpathologie
- Cancer evolution is a step-wise non-linear process that may start early in life or later in adulthood, and includes pre-malignant (indolent) and malignant phases. Early somatic changes may not be detectable or are found by chance in apparently healthy individuals. The same lesions may be detected in pre-malignant clonal conditions. In some patients, these lesions may never become relevant clinically whereas in others, they act together with additional pro-oncogenic hits and thereby contribute to the formation of an overt malignancy. Although some pre-malignant stages of a malignancy have been characterized, no global system to define and to classify these conditions is available. To discuss open issues related to pre-malignant phases of neoplastic disorders, a working conference was organized in Vienna in August 2015. The outcomes of this conference are summarized herein and include a basic proposal for a nomenclature and classification of pre-malignant conditions. This proposal should assist in the communication among patients, physicians and scientists, which is critical as genome-sequencing will soon be offered widely for early cancer-detection.Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.
Cell Transformation, Neoplasticgenetics