Veterinärmedizinische Universität Wien Forschungsinformationssystem VetDoc

Grafischer Link zur Startseite der Vetmeduni Vienna

Gewählte Publikation:

Open Access Logo

Publikationstyp: Zeitschriftenaufsatz
Dokumenttyp: Originalarbeit

Jahr: 2016

AutorInnen: Eder, T; Grebien, F; Rattei, T

Titel: NVT: a fast and simple tool for the assessment of RNA-seq normalization strategies.

Quelle: Bioinformatics. 2016; 32(23):3682-3684



Autor/innen der Vetmeduni Vienna:

Grebien Florian

Diese Publikation wurde nicht im Namen der Vetmeduni Vienna erstellt und ist deshalb ausschließlich der persönlichen Publikationsliste des/der Autors/Autorin zugeordnet!


Abstract:
Measuring differential gene expression is a common task in the analysis of RNA-Seq data. To identify differentially expressed genes between two samples, it is crucial to normalize the datasets. While multiple normalization methods are available, all of them are based on certain assumptions that may or may not be suitable for the type of data they are applied on. Researchers therefore need to select an adequate normalization strategy for each RNA-Seq experiment. This selection includes exploration of different normalization methods as well as their comparison. Methods that agree with each other most likely represent realistic assumptions under the particular experimental conditions.

Keywords Pubmed: Computational Biology/methods
Humans
RNA/genetics*
Sequence Analysis, RNA/methods*
Software*


© Veterinärmedizinische Universität Wien Hilfe und DownloadsErklärung zur Barrierefreiheit