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Gewählte Publikation:

Publikationstyp: Zeitschriftenaufsatz
Dokumentart: Originalarbeit

Publikationsjahr: 2015

AutorInnen: Locker, F; Lang, AA; Koller, A; Lang, R; Bianchini, R; Kofler, B

Titel: Galanin modulates human and murine neutrophil activation in vitro.

Quelle: Acta Physiol (Oxf). 2015; 213(3):595-602



Autor/innen der Vetmeduni Vienna:

Locker Felix

Diese Publikation wurde nicht im Namen der Vetmeduni Vienna erstellt und ist deshalb ausschließlich der persönlichen Publikationsliste des/der Autors/Autorin zugeordnet!


Abstract:
Polymorphonuclear neutrophils are key players in innate immunity. The innate immune system needs to be tightly controlled to ensure proper activation but also no overactivation. Galanin has been shown to regulate inflammatory reactions, and therefore, we aimed to elucidate the expression of galanin and its three receptors (GAL1 -GAL3 ) in polymorphonuclear neutrophils and to evaluate whether galanin exerts direct or indirect effects on human and murine polymorphonuclear neutrophils.

Keywords Pubmed: Amides/pharmacology*
Animals
CD11b Antigen/metabolism
Cells, Cultured
Dose-Response Relationship, Drug
Female
Galanin/pharmacology*
Humans
Immunity, Innate/drug effects
Immunologic Factors/pharmacology*
Interleukin-8/metabolism
Male
Mice, Inbred C57BL
Neutrophil Activation/drug effects*
Neutrophils/drug effects*
Neutrophils/immunology
Neutrophils/metabolism
RNA, Messenger/metabolism
Receptors, Galanin/agonists
Receptors, Galanin/genetics
Receptors, Galanin/metabolism


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