Veterinärmedizinische Universität Wien Forschungsinformationssystem VetDoc

Grafischer Link zur Startseite der Vetmeduni Vienna

Gewählte Publikation:

Publikationstyp: Zeitschriftenaufsatz
Dokumentart: Originalarbeit

Publikationsjahr: 2019

AutorInnen: Simonović, N; Witalisz-Siepracka, A; Meissl, K; Lassnig, C; Reichart, U; Kolbe, T; Farlik, M; Bock, C; Sexl, V; Müller, M; Strobl, B

Titel: NK Cells Require Cell-Extrinsic and -Intrinsic TYK2 for Full Functionality in Tumor Surveillance and Antibacterial Immunity.

Quelle: J Immunol. 2019; 202(6):1724-1734



Autor/innen der Vetmeduni Vienna:

Kolbe Thomas,
Lassnig Caroline,
Meißl Katrin,
Müller Mathias,
Reichart Ursula,
Sexl Veronika,
Simonovic Natalija,
Strobl Birgit,
Witalisz-Siepracka Agnieszka Anna,

Beteiligte Vetmed-Organisationseinheiten
Abteilung für Molekulare Genetik,
Institut für Pharmakologie und Toxikologie,


Zugehörige(s) Projekt(e): Tyk2 in der angeborenen Immunantwort während Sepsis


Abstract:
Tyrosine kinase 2 (TYK2) is a widely expressed receptor-associated kinase that is involved in signaling by a variety of cytokines with important immune regulatory activities. Absence of TYK2 in mice results in impaired NK cell maturation and antitumor activity, although underlying mechanisms are largely unknown. Using conditional ablation of TYK2 in NK cells we show that TYK2 is required for IFN-γ production by NK cells in response to IL-12 and for an efficient immune defense against Listeria monocytogenes Deletion of TYK2 in NK cells did not impact NK cell maturation and IFN-γ production upon NK cell activating receptor (actR) stimulation. Similarly, NK cell-mediated tumor surveillance was unimpaired upon deletion of TYK2 in NK cells only. In line with the previously reported maturation-associated Ifng promoter demethylation, the less mature phenotype of Tyk2


© Veterinärmedizinische Universität Wien Hilfe und Downloads