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Gewählte Publikation:

Publikationstyp: Zeitschriftenaufsatz
Dokumentart: Originalarbeit

Publikationsjahr: 2019

AutorInnen: Simonović, N; Witalisz-Siepracka, A; Meissl, K; Lassnig, C; Reichart, U; Kolbe, T; Farlik, M; Bock, C; Sexl, V; Müller, M; Strobl, B

Titel: NK Cells Require Cell-Extrinsic and -Intrinsic TYK2 for Full Functionality in Tumor Surveillance and Antibacterial Immunity.

Quelle: J Immunol. 2019; 202(6):1724-1734



Autor/innen der Vetmeduni Vienna:

Kolbe Thomas
Lassnig Caroline
Meißl Katrin
Müller Mathias
Reichart Ursula
Sexl Veronika
Simonovic Natalija
Strobl Birgit
Witalisz-Siepracka Agnieszka Anna

Beteiligte Vetmed-Organisationseinheiten
Abteilung für Molekulare Genetik
Institut für Pharmakologie und Toxikologie


Zugehörige(s) Projekt(e): Tyk2 in der angeborenen Immunantwort während Sepsis


Abstract:
Tyrosine kinase 2 (TYK2) is a widely expressed receptor-associated kinase that is involved in signaling by a variety of cytokines with important immune regulatory activities. Absence of TYK2 in mice results in impaired NK cell maturation and antitumor activity, although underlying mechanisms are largely unknown. Using conditional ablation of TYK2 in NK cells we show that TYK2 is required for IFN-γ production by NK cells in response to IL-12 and for an efficient immune defense against Listeria monocytogenes Deletion of TYK2 in NK cells did not impact NK cell maturation and IFN-γ production upon NK cell activating receptor (actR) stimulation. Similarly, NK cell-mediated tumor surveillance was unimpaired upon deletion of TYK2 in NK cells only. In line with the previously reported maturation-associated Ifng promoter demethylation, the less mature phenotype of Tyk2


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