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Gewählte Publikation:

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Publikationstyp: Zeitschriftenaufsatz
Dokumenttyp: Originalarbeit

Jahr: 2019

AutorInnen: Jordakieva, G; Kundi, M; Untersmayr, E; Pali-Schöll, I; Reichardt, B; Jensen-Jarolim, E

Titel: Country-wide medical records infer increased allergy risk of gastric acid inhibition.

Quelle: Nat Commun. 2019; 10(1):3298



Autor/innen der Vetmeduni Vienna:

Jensen-Jarolim Erika
Pali Isabella

Beteiligte Vetmed-Organisationseinheiten
Messerli Forschungsinstitut, Abteilung für Komparative Medizin


Zugehörige(s) Projekt(e): Entwicklung von Mimotop-Vakzinen für präklinische und komparative Medizin Studien


Abstract:
Gastric acid suppression promotes allergy in mechanistic animal experiments and observational human studies, but whether gastric acid inhibitors increase allergy incidence at a population level remains uncharacterized. Here we aim to assess the use of anti-allergic medication following prescription of gastric acid inhibitors. We analyze data from health insurance records covering 97% of Austrian population between 2009 and 2013 on prescriptions of gastric acid inhibitors, anti-allergic drugs, or other commonly prescribed (lipid-modifying and antihypertensive) drugs as controls. Here we show that rate ratios for anti-allergic following gastric acid-inhibiting drug prescriptions are 1.96 (95%CI:1.95-1.97) and 3.07 (95%-CI:2.89-3.27) in an overall and regional Austrian dataset. These findings are more prominent in women and occur for all assessed gastric acid-inhibiting substances. Rate ratios increase from 1.47 (95%CI:1.45-1.49) in subjects <20 years, to 5.20 (95%-CI:5.15-5.25) in > 60 year olds. We report an epidemiologic relationship between gastric acid-suppression and development of allergic symptoms.

Keywords Pubmed: Adolescent
Adult
Aged
Anti-Ulcer Agentsadverse effectstherapeutic use
Austriaepidemiology
Female
Gastric Acidchemistry
Humans
Hypersensitivityepidemiologyetiologyimmunology
Immune Systemdrug effectsimmunology
Incidence
Male
Medical Recordsstatistics & numerical data
Middle Aged
Proton Pump Inhibitorsadverse effectstherapeutic use
Young Adult

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