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Gewählte Publikation:

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Publikationstyp: Zeitschriftenaufsatz
Dokumenttyp: Übersichtsarbeit

Jahr: 2020

AutorInnen: Ferastraoaru, D; Bax, HJ; Bergmann, C; Capron, M; Castells, M; Dombrowicz, D; Fiebiger, E; Gould, HJ; Hartmann, K; Jappe, U; Jordakieva, G; Josephs, DH; Levi-Schaffer, F; Mahler, V; Poli, A; Rosenstreich, D; Roth-Walter, F; Shamji, M; Steveling-Klein, EH; Turner, MC; Untersmayr, E; Karagiannis, SN; Jensen-Jarolim, E

Titel: AllergoOncology: Ultra-low IgE, a potential novel biomarker in cancer - A Position Paper of the European Academy of Allergy and Clinical Immunology (EAACI).

Quelle: Clinical and Translational Allergy 2020; 10: 32



Autor/innen der Vetmeduni Vienna:

Jensen-Jarolim Erika
Roth-Walter Franziska

Beteiligte Vetmed-Organisationseinheiten
Messerli Forschungsinstitut, Abteilung für Komparative Medizin


Zugehörige(s) Projekt(e): Entwicklung von Mimotop-Vakzinen für präklinische und komparative Medizin Studien


Abstract:
Elevated serum IgE levels are associated with allergic disorders, parasitosis and specific immunologic abnormalities. In addition, epidemiological and mechanistic evidence indicates an association between IgE-mediated immune surveillance and protection from tumour growth. Intriguingly, recent studies reveal a correlation between IgE deficiency and increased malignancy risk. This is the first review discussing IgE levels and links to pathological conditions, with special focus on the potential clinical significance of ultra-low serum IgE levels and risk of malignancy. In this Position Paper we discuss: (a) the utility of measuring total IgE levels in the management of allergies, parasitosis, and immunodeficiencies, (b) factors that may influence serum IgE levels, (c) IgE as a marker of different disorders, and d) the relationship between ultra-low IgE levels and malignancy susceptibility. While elevated serum IgE is generally associated with allergic/atopic conditions, very low or absent IgE may hamper anti-tumour surveillance, indicating the importance of a balanced IgE-mediated immune function. Ultra-low IgE may prove to be an unexpected biomarker for cancer risk. Nevertheless, given the early stage of investigations conducted mostly in patients with diseases that influence IgE levels, in-depth mechanistic studies and stratification of malignancy risk based on associated demographic, immunological and clinical co-factors are warranted.


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