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Publikationstyp: Zeitschriftenaufsatz
Dokumenttyp: Originalarbeit

Jahr: 2021

AutorInnen: Veith, VK; Quigley, C; Treue, S

Titel: Cholinergic manipulations affect sensory responses but not attentional enhancement in macaque MT.

Quelle: BMC Biol. 2021; 19(1):49

Autor/innen der Vetmeduni Vienna:

Quigley Cliodhna

Beteiligte Vetmed-Organisationseinheiten
Konrad Lorenz Institut für Vergleichende Verhaltensforschung, Abteilung für Ornithologie

Attentional modulation in the visual cortex of primates is characterized by multiplicative changes of sensory responses with changes in the attentional state of the animal. The cholinergic system has been linked to such gain changes in V1. Here, we aim to determine if a similar link exists in macaque area MT. While rhesus monkeys performed a top-down spatial attention task, we locally injected a cholinergic agonist or antagonist and recorded single-cell activity.Although we confirmed cholinergic influences on sensory responses, there was no additional cholinergic effect on the attentional gain changes. Neither a muscarinic blockage nor a local increase in acetylcholine led to a significant change in the magnitude of spatial attention effects on firing rates.This suggests that the cellular mechanisms of attentional modulation in the extrastriate cortex cannot be directly inferred from those in the primary visual cortex.

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