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Gewählte Publikation:

Publikationstyp: Zeitschriftenaufsatz
Dokumenttyp: Übersichtsarbeit

Jahr: 2007

AutorInnen: Krausz, LT; Bianchini, R; Ronchetti, S; Fettucciari, K; Nocentini, G; Riccardi, C

Titel: GITR-GITRL system, a novel player in shock and inflammation.

Quelle: ScientificWorldJournal. 2007; 7:533-66



Autor/innen der Vetmeduni Vienna:

Bianchini Rodolfo

Diese Publikation wurde nicht im Namen der Vetmeduni Vienna erstellt und ist deshalb ausschließlich der persönlichen Publikationsliste des/der Autors/Autorin zugeordnet!


Abstract:
Glucocorticoid-induced TNFR-Related (GITR) protein is a member of the tumor necrosis factor receptor superfamily that modulates acquired and natural immune response. It is expressed in several cells and tissues, including T cells, natural killer cells, and, at lower levels, in cells of innate immunity. GITR is activated by its ligand, GITRL, mainly expressed on antigen presenting and endothelial cells. Recent evidence suggests that the GITR/GITRL system participates in the development of inflammatory responses, including shock, either due to early response of neutrophils and macrophages, or together with autoimmune/allergic pathogenesis. The pro-inflammatory role of the GITR/GITRL system is due to: 1) modulation of the extravasation process, 2) activation of innate immunity cells, 3) activation of effector T cells also favored by partial inhibition of suppressor T cells and modulation of dendritic function. This review summarizes the in vivo role of the GITR/GITRL system in inflammation and shock, explaining the mechanisms responsible for their effects, considering the interplay among the different cells of the immune system and transduction pathways activated by GITR and GITRL triggering. The hidden aspects about GITR/GITRL function, crucial for treatment planning of inflammatory diseases and shock by modulation of this system is stressed.

Keywords Pubmed: Animals
Glucocorticoid-Induced TNFR-Related Proteinchemistrygeneticsmetabolism
Humans
Inflammationgeneticsimmunologymetabolismpathology
Protein Binding
Receptors, Nerve Growth Factorgeneticsmetabolism
Receptors, Tumor Necrosis Factorgeneticsmetabolism
Shockgeneticsimmunologymetabolismpathology

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