University of Veterinary Medicine Vienna - Research portal
Selected Publication:
Type of publication:
Baccalaureate Thesis
Type of document:
Year:
2011
Authors:
Scholl, Theresa
Title:
Characterisation and treatment of a NPM-ALK positive ALCL mouse model.
Other title:
Charakterisierung und Behandlung eines NPM-ALK positiven ALCL Maus Modells
Source:
Bakkalaureatsarbeit, Vet. Med. Univ. Wien, pp. 28.
Advisor(s):
Reviewer(s):
-
Vetmed Research Units:
- Institute of Morphology
Graduation date:
26.09.11
- The first description of the anaplastic large cell lymphoma (ALCL) took place in 1985 (STEIN et al., 1985). It is a high malignant T-cell neoplasm with predominant nodular- or extranodular types (DIEBOLD, 2001). Some of these lymphomas have a chromosomal translocation, which results in a fusion of nucleophosmin (NPM) and the anaplastic lymphoma kinase (ALK). The resulting protein (p80) is responsible for the pathogenesis and relevant for diagnose and therapy. The so-called NPM-ALK positive ALCL is mainly found in young adolescence (FALINI et al., 2009). The treatment of patients with ALCL is based on the same chemotherapeutics (CHOP-based regimens) as used for diffuse large B-cell lymphoma patients. About 80% of the children and 60% of the adults suffering from ALK positive lymphomas are cured by this therapy (FALINI et al., 1999). However, there is a novel therapy approach for healing this kind of lymphoma. Scientists from the medical university of Vienna found that there exists an overexpression of the PDGFR-ß in murine and also in human NPM-ALK positive ALCL.
Abstract: