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Type of publication: Journal Article
Type of document: Review

Year: 2011

Authors: Yunus, AW; Razzazi-Fazeli, E; Bohm, J

Title: Aflatoxin B(1) in affecting broiler"s performance, immunity, and gastrointestinal tract: a review of history and contemporary issues.

Source: Toxins (Basel). 2011; 3(6):566-590



Authors Vetmeduni Vienna:

Böhm Josef
Razzazi-Fazeli Ebrahim

Vetmed Research Units
Institute of Animal Nutrition and Functional Plant Compounds
VetCore


Abstract:
Aflatoxin B(1) is a common contaminant of poultry feeds in tropical and subtropical climates. Research during the last five decades has well established the negative effects of the mycotoxin on health of poultry. However, the last ten years of relevant data have accentuated the potential of low levels of aflatoxin B(1) to deteriorate broiler performance. In this regard, any attempt to establish a dose-effect relationship between aflatoxin B(1) level and broiler performance is also complicated due to differences in types of broilers and length of exposure to the mycotoxin in different studies. Contrary to the prevalent notion regarding literature saturation with respect to aflatoxicosis of chicken, many areas of aflatoxicosis still need to be explored. Literature regarding effects of the mycotoxin on the gastrointestinal tract in this regard is particular scanty and non-conclusive. In addition to these issues, the metabolism of aflatoxin B(1) and recently proposed hypotheses regarding biphasic effects of the mycotoxin in broilers are briefly discussed.

Keywords Pubmed: Aflatoxin B1/metabolism
Aflatoxin B1/pharmacokinetics
Aflatoxin B1/toxicity*
Animal Feed*/adverse effects
Animal Feed*/microbiology
Animals
Aspergillus/growth & development*
Aspergillus/metabolism
Chickens*/blood
Chickens*/growth & development
Chickens*/immunology
Eating/drug effects
Gastrointestinal Tract/drug effects*
Gastrointestinal Tract/metabolism
Gastrointestinal Tract/pathology
Immunity, Cellular/drug effects
Immunity, Humoral/drug effects
Lethal Dose 50
Organ Size/drug effects
Organ Specificity
Weight Gain/drug effects


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