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Selected Publication:

Type of publication: Journal Article
Type of document: Full Paper

Year: 2013

Authors: Liebhart, D; Sulejmanovic, T; Grafl, B; Tichy, A; Hess, M

Title: Vaccination against histomonosis prevents a drop in egg production in layers following challenge.

Source: Avian Pathol. 2013; 42(1):79-84



Authors Vetmeduni Vienna:

Grafl Beatrice
Hess Michael
Liebhart Dieter
Sulejmanovic Tarik
Tichy Alexander

Vetmed Research Units
University Clinic for Poultry and Fish Medicine, Clinical Unit of Poultry Medicine
Platform Bioinformatics and Biostatistics


Abstract:
The effect of attenuated Histomonas meleagridis on pullets was investigated and the protection of vaccinated adult laying hens against a severe challenge was studied in the same experimental setting. Four groups of 25 pullets were set up at 18 weeks of life and birds in two groups were vaccinated with in vitro-attenuated H. meleagridis. Chickens in two groups (vaccinated and non-vaccinated) were challenged 5 weeks later with virulent histomonads, while the remaining groups were retained until termination of the study 11 weeks post vaccination. Vaccination of pullets did not have any impact on their subsequent performance. Egg production of non-vaccinated but challenged birds dropped significantly (P ≤ 0.05) between 2 and 4 weeks post challenge (p.c.) to 58.7%, compared with 90% in control chickens. At 4 weeks p.c., the drop in egg production in vaccinated and challenged birds was significantly lower (P=0.02) than in non-protected layers. Pathological changes were found only in challenged birds 2 and 6 weeks p.c. Several non-vaccinated birds showed severe lesions in the caeca with sporadic involvement of the liver and atrophy of the reproductive tract. Vaccination prior to challenge reduced the incidence of pathological findings. For the first time, vaccination of pullets with in vitro-attenuated histomonads could be shown to be an effective and safe prophylactic tool to prevent a severe drop in egg production of commercial layers following experimental infection.

Keywords Pubmed: Animals
Antibodies, Protozoan/blood
Body Weight
Cecum/pathology
Chickens/parasitology
Chickens/physiology*
Eggs
Female
Liver/pathology
Ovary/pathology
Oviducts/pathology
Poultry Diseases/parasitology
Poultry Diseases/physiopathology
Poultry Diseases/prevention & control*
Protozoan Infections, Animal/parasitology
Protozoan Infections, Animal/physiopathology
Protozoan Infections, Animal/prevention & control*
Protozoan Vaccines*/adverse effects
Protozoan Vaccines*/immunology
Trichomonadida/immunology*
Trichomonadida/pathogenicity
Vaccination/veterinary
Vaccines, Attenuated/adverse effects
Vaccines, Attenuated/immunology
Virulence


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