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Type of publication: Journal Article
Type of document: Full Paper

Year: 2019

Authors: Awad, WA; Ruhnau, D; Hess, C; Doupovec, B; Schatzmayr, D; Hess, M

Title: Feeding of deoxynivalenol increases the intestinal paracellular permeability of broiler chickens.

Source: Arch Toxicol. 2019; 93(7):2057-2064

Authors Vetmeduni Vienna:

Awad Wageha
Hess Claudia
Hess Michael
Ruhnau Daniel

Vetmed Research Units
University Clinic for Poultry and Fish Medicine, Clinical Unit of Poultry Medicine

Project(s): Selected nutrition-related strategies to reduce the Campylobacter burden in chickens

In recent years, the deleterious effects attributed to mycotoxins, in particular on the intestine, faced increased attention and it was shown that deoxynivalenol (DON) causes adverse effects on gut health. In this context, it has been repeatedly reported that DON can alter the intestinal morphology, disrupt the intestinal barrier and reduce nutrient absorption. The underlying mechanism of a compromised intestinal barrier caused by DON in chickens has yet to be illustrated. Although, DON is rapidly absorbed from the upper parts of the small intestine, the effects on the large intestine cannot be excluded. Additionally, a damaging effect of DON on the gut epithelium might decrease the resistance of the gut against infectious agents. Consequently, the objectives of the present studies were: (1) to investigate the impact of DON on the epithelial paracellular permeability by demonstrating the mucosal to serosal flux of

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