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Type of publication: Journal Article
Type of document: Full Paper

Year: 2021

Authors: Lado, S; Elbers, JP; Plasil, M; Loney, T; Weidinger, P; Camp, JV; Kolodziejek, J; Futas, J; Kannan, DA; Orozco-terWengel, P; Horin, P; Nowotny, N; Burger, PA

Title: Innate and Adaptive Immune Genes Associated with MERS-CoV Infection in Dromedaries.

Source: Cells. 2021; 10(6):1291

Authors Vetmeduni Vienna:

Burger Pamela
Camp Jeremy
Elbers Jean Pierre
Kolodziejek Jolanta
Nowotny Norbert
Ribeiro Barbosa Almendra Lado Sara
Weidinger Pia

Vetmed Research Units
Institute of Virology
Research Institute of Wildlife Ecology

Project(s): Characterization of the immunogenome in Old World camelids

The recent SARS-CoV-2 pandemic has refocused attention to the betacoronaviruses, only eight years after the emergence of another zoonotic betacoronavirus, the Middle East respiratory syndrome coronavirus (MERS-CoV). While the wild source of SARS-CoV-2 may be disputed, for MERS-CoV, dromedaries are considered as source of zoonotic human infections. Testing 100 immune-response genes in 121 dromedaries from United Arab Emirates (UAE) for potential association with present MERS-CoV infection, we identified candidate genes with important functions in the adaptive, MHC-class I (HLA-A-24-like) and II (HLA-DPB1-like), and innate immune response (PTPN4, MAGOHB), and in cilia coating the respiratory tract (DNAH7). Some of these genes previously have been associated with viral replication in SARS-CoV-1/-2 in humans, others have an important role in the movement of bronchial cilia. These results suggest similar host genetic pathways associated with these betacoronaviruses, although further work is required to better understand the MERS-CoV disease dynamics in both dromedaries and humans.

Keywords Pubmed: Adaptive Immunitygenetics
Antibodies, Viral
Communicable Diseases, Emerginggeneticsimmunologytransmissionvirology
Coronavirus Infectionsgeneticsimmunologytransmissionvirology
Disease Reservoirsvirology
Genetic Predisposition to Disease
Host Microbial Interactionsgeneticsimmunology
Immunity, Innategenetics
Middle East Respiratory Syndrome Coronavirusimmunologyisolation & purificationpathogenicity
Respiratory Mucosacytologyphysiology
United Arab Emirates
Virus Replicationgeneticsimmunology

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