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Selected Publication:

Type of publication: Journal Article
Type of document: Full Paper

Year: 1992


Title: Genomic organization and analysis of the 5' end of the porcine ryanodine receptor gene (ryr1).

Source: FEBS Lett (298), 2-3 277-279.

Authors Vetmeduni Vienna:

Brem Gottfried

In this study we describe the isolation of genomic clones of the 5' region of the porcine ryanodine receptor gene, a candidate for malignant hyperthermia in pigs and humans. The recombinants were isolated from a porcine liver, genomic DNA library in phage EMBL3A after screening with PCR amplified DNA fragments. The exon/intron structure of the ryanodine receptor gene was determined by DNA sequencing. Based on the sequence data it was possible to develop a simple test for the detection of malignant hyperthermia susceptible and normal pigs.

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