University of Veterinary Medicine Vienna - Research portal

Diagrammed Link to Homepage University of Veterinary Medicine, Vienna

Selected Publication:

Type of publication: Journal Article
Type of document: Full Paper

Year: 1992

Authors:

Title: Genomic organization and analysis of the 5' end of the porcine ryanodine receptor gene (ryr1).

Source: FEBS Lett (298), 2-3 277-279.



Authors Vetmeduni Vienna:

Brem Gottfried


Abstract:
In this study we describe the isolation of genomic clones of the 5' region of the porcine ryanodine receptor gene, a candidate for malignant hyperthermia in pigs and humans. The recombinants were isolated from a porcine liver, genomic DNA library in phage EMBL3A after screening with PCR amplified DNA fragments. The exon/intron structure of the ryanodine receptor gene was determined by DNA sequencing. Based on the sequence data it was possible to develop a simple test for the detection of malignant hyperthermia susceptible and normal pigs.


© University of Veterinary Medicine ViennaHelp and Downloads