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Publication type: Journal Article
Document type: Full Paper

Year: 2016

Author(s): Matos, M; Grafl, B; Liebhart, D; Hess, M

Title: The outcome of experimentally induced inclusion body hepatitis (IBH) by fowl aviadenoviruses (FAdVs) is crucially influenced by the genetic background of the host.

Source: Vet Res. 2016; 47(1):69



Authors Vetmeduni Vienna:

Carvalho dos Reis Branco de Matos Jorge Miguel
Grafl Beatrice
Hess Michael
Liebhart Dieter

Vetmed Research Units
University Clinic for Poultry and Fish Medicine, Clinical Unit of Poultry Medicine


Abstract:
In the present study, inclusion body hepatitis (IBH) was experimentally induced by oral inoculation of two groups of specific pathogen-free (SPF) broilers and two groups of SPF layers at day-old with either a fowl aviadenovirus (FAdV)-D or a FAdV-E strain. A substantial variation in the degree of susceptibility was observed with mortalities of 100 and 96% in the FAdV-E and D infected SPF broiler groups, respectively, whereas in the groups of infected SPF layers mortalities of only 20 and 8% were noticed. Significant changes in clinical chemistry analytes of all infected birds together with histopathological lesions indicated impairment of liver and pancreas integrity and functions. Furthermore, significantly lower blood glucose concentrations were recorded at peak of infection in both inoculated SPF broiler groups, in comparison to the control group, corresponding to a hypoglycaemic status. High viral loads were determined in liver and pancreas of SPF broilers already at 4 days post-infection (dpi), in comparison to SPF layers, indicating a somewhat faster viral replication in the target organs. Overall, highest values were noticed in the pancreas of SPF broilers independent of the virus used for infection. The actual study provides new insights into the pathogenesis of IBH, a disease evolving to a metabolic disorder, to which SPF broilers were highly susceptible. Hence, this is the first study to report a significant higher susceptibility of SPF broiler chickens to experimentally induced IBH in direct comparison to SPF layers.

Keywords Pubmed: Adenoviridae Infections/mortality
Adenoviridae Infections/veterinary*
Adenoviridae Infections/virology
Animals
Aviadenovirus/pathogenicity*
Genetic Background*
Genetic Predisposition to Disease/genetics
Hepatitis, Viral, Animal/genetics
Hepatitis, Viral, Animal/mortality
Hepatitis, Viral, Animal/virology*
Inclusion Bodies, Viral/pathology
Inclusion Bodies, Viral/virology*
Liver/pathology
Liver/virology
Pancreas/pathology
Pancreas/virology
Poultry Diseases/genetics
Poultry Diseases/mortality
Poultry Diseases/virology*
Viral Load


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