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Type of publication: Journal Article
Type of document: Full Paper

Year: 2018

Authors: Ribitsch, I; Peham, C; Ade, N; Dürr, J; Handschuh, S; Schramel, JP; Vogl, C; Walles, H; Egerbacher, M; Jenner, F

Title: Structure-Function relationships of equine menisci.

Source: PLoS One. 2018; 13(3):e0194052

Authors Vetmeduni Vienna:

Egerbacher Monika
Gerner Iris
Handschuh Stephan
Jenner Florien
Peham Christian
Schramel Johannes
Vogl Claus

Vetmed Research Units
University Clinic for Small Animals, Clinical Unit of Anaesthesiology and Perioperative Intensive-Care Medicine
University Equine Clinic, Clinical Unit of Equine Surgery
Institute of Pathology
Institute of Animal Breeding and Genetics, Unit of Molecular Genetics

Meniscal pathologies are among the most common injuries of the femorotibial joint in both human and equine patients. Pathological forces and ensuing injuries of the cranial horn of the equine medial meniscus are considered analogous to those observed in the human posterior medial horn. Biomechanical properties of human menisci are site- and depth- specific. However, the influence of equine meniscus topography and composition on its biomechanical properties is yet unknown. A better understanding of equine meniscus composition and biomechanics could advance not only veterinary therapies for meniscus degeneration or injuries, but also further substantiate the horse as suitable translational animal model for (human) meniscus tissue engineering. Therefore, the aim of this study was to investigate the composition and structure of the equine knee meniscus in a site- and age-specific manner and their relationship with potential site-specific biomechanical properties. The meniscus architecture was investigated histologically. Biomechanical testing included evaluation of the shore hardness (SH), stiffness and energy loss of the menisci. The SH was found to be subjected to both age and site-specific changes, with an overall higher SH of the tibial meniscus surface and increase in SH with age. Stiffness and energy loss showed neither site nor age related significant differences. The macroscopic and histologic similarities between equine and human menisci described in this study, support continued research in this field.

Keywords Pubmed: Aging
Biomechanical Phenomena
Compressive Strength
Hardness Tests
Horsesanatomy & histology
Meniscusanatomy & histologychemistryphysiology
Stifleanatomy & histologyphysiology
Structure-Activity Relationship
X-Ray Microtomography

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