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Selected Publication:

[Article in Press]

Type of publication: Journal Article
Type of document: Full Paper

Year: 2021

Authors: Austin, S; Nowikovsky, K

Title: Mitochondrial osmoregulation in evolution, cation transport and metabolism.

Source: Biochim Biophys Acta Bioenerg. 2021; 148368



Authors Vetmeduni Vienna:

Nowikovsky Karin

Vetmed Research Units
Institute of Physiology, Pathohysiology and Biophysics, Unit of Physiology and Biophysics


Project(s): Characterization of the Novel LETM1 Interaction Partner TMBIM5

Cross-Communication between Succinate Dehydrogenase and Fatty Acid Biosynthesis


Abstract:
This review provides a retrospective on the role of osmotic regulation in the process of eukaryogenesis. Specifically, it focuses on the adjustments which must have been made by the original colonizing α-proteobacteria that led to the evolution of modern mitochondria. We focus on the cations that are fundamentally involved in volume determination and cellular metabolism and define the transporter landscape in relation to these ions in mitochondria as we know today. We provide analysis on how the cations interplay and together maintain osmotic balance that allows for effective ATP synthesis in the organelle.Copyright © 2021. Published by Elsevier B.V.


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