[Article in Press]
Type of publication:
Type of document:
Austin, S; Nowikovsky, K
Mitochondrial osmoregulation in evolution, cation transport and metabolism.
Biochim Biophys Acta Bioenerg. 2021; 148368
Authors Vetmeduni Vienna:
Vetmed Research Units
Institute of Physiology, Pathohysiology and Biophysics, Unit of Physiology and Biophysics
Characterization of the Novel LETM1 Interaction Partner TMBIM5
Cross-Communication between Succinate Dehydrogenase and Fatty Acid Biosynthesis
- This review provides a retrospective on the role of osmotic regulation in the process of eukaryogenesis. Specifically, it focuses on the adjustments which must have been made by the original colonizing α-proteobacteria that led to the evolution of modern mitochondria. We focus on the cations that are fundamentally involved in volume determination and cellular metabolism and define the transporter landscape in relation to these ions in mitochondria as we know today. We provide analysis on how the cations interplay and together maintain osmotic balance that allows for effective ATP synthesis in the organelle.Copyright © 2021. Published by Elsevier B.V.