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Selected Publication:

Type of publication: Journal Article
Type of document: Short Communication

Year: 2021

Authors: Unterweger, C; Brunthaler, R; Auer, A; Fux, R; Weissenbacher-Lang, C; Ladinig, A

Title: Reconsideration of the diagnostic criteria required for PCV2 reproductive disease.

Source: Vet J. 2021; 272:105660



Authors Vetmeduni Vienna:

Auer Angelika
Brunthaler Rene
Ladinig Andrea
Unterweger Christine
Weissenbacher-Lang Christiane

Vetmed Research Units
Institute of Pathology
Institute of Virology
University Clinic for Swine


Abstract:
Porcine circovirus type 2 (PCV2) causes a variety of clinical conditions including PCV2-associated reproductive disease (PCV2-RD) characterized by late term abortions and mummifications. The generally accepted diagnostic triad includes the presence of reproductive disorders, the histopathological finding of myocarditis, and detection of moderate to high viral loads within the heart tissue. A new threshold of 109 PCV2 genome equivalents (GE)/g heart tissue is suggested to fulfil the third criterion using the diagnostic settings of quantitative real time PCR and in situ hybridization of 30 fetal heart tissues. The need to identify histopathological lesions in fetal heart tissue appears to be invalid or overestimated in confirming a diagnosis of PCV2-RD, at least at the individual fetus level. The highest viral loads (1012 GE/g tissue) were detected in autolyzed and mummified piglets and were identified as PCV2d, although concurrent detection of PCV2d + a and PCV2d + b also occurred.Copyright © 2021. Published by Elsevier Ltd.


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