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Type of publication: Journal Article
Type of document: Full Paper

Year: 2022

Authors: Druml, T; Brem, G; Horna, M; Ricard, A; Grilz-Seger, G

Title: DPF3, A Putative Candidate Gene For Melanoma Etiopathogenesis in Gray Horses.

Source: J Equine Vet Sci. 2022; 108:103797

Authors Vetmeduni Vienna:

Brem Gottfried
Druml Thomas
Grilz-Seger Gertrud

Vetmed Research Units
Institute of Animal Breeding and Genetics, Unit of Reproductive Biology

Project(s): Genetic analyses of coat colors with regard to practical breeding andconservation genetics in the Lipizzan, Noriker horse breed and theWeiße Barockesel breed

Melanoma prevalence in gray horses reaches up to 50% and more. Several studies have documented a genetic melanoma predisposition which is referred to the 4.6 kb duplication in intron 6 of STX17 and its surrounding haplotype. However, the genetic background and mechanisms responsible for differences in etiopathogenesis of equine dermal melanomatosis still remain unknown. In the current study, we performed a genome wide association analysis in 141 Lipizzan horses and subsequently identified one candidate gene on chromosome 24 putatively involved in melanoma pathogenesis in gray horses. The associated SNP was located in the intronic region of DPF3, a gene which is involved in humans in cell growth, proliferation, apoptosis and motility of cancer cells. The replication study in 1210 horses from seven breeds demonstrated, that the G/G genotype of the DPF3 associated SNP exhibits putative melanoma suppression effects. As a conclusion DPF3 represents a candidate gene, which might play an essential role for gray horses coping with high genetic melanoma related tumor load.Copyright © 2021. Published by Elsevier Inc.

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