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Selected Publication:

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Type of publication: PhD Thesis
Type of document:

Year: 2013

Authors: Mair, Kerstin

Title: NKp46-defined porcine Natural Killer cells: phenotypical and functional characterisation.

Source: PhD-Arbeit, Vet. Med. Univ. Wien, pp. 95.


Saalmüller Armin

Vetmed Research Units:
Institute of Immunology

Graduation date: 12.03.13

Natural killer (NK) cells are a specialised subpopulation of lymphocytes involved in immune responses against pathogenic microorganisms and tumours. Although the pig is an important farm animal species and highly qualified as a model-organism for humans, to date only little information about porcine NK cells is available. Since porcine NK-cell markers established up to now are also expressed on other cell populations like T cells, γδ T cells and macrophages, the precise identification and thus more detailed characterisation of porcine NK cells was difficult so far. Consequently, the aim of this work was to enable a more detailed phenotypical and functional analysis of NK cells in this species.

Publication(s) resulting from University thesis:

Mair, KH; Müllebner, A; Essler, SE; Duvigneau, JC; Storset, AK; Saalmüller, A; Gerner, W (2013): Porcine CD8αdim/-NKp46high NK cells are in a highly activated state. Vet Res. 2013; 44:13
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Mair, KH; Essler, SE; Patzl, M; Storset, AK; Saalmüller, A; Gerner, W (2012): NKp46 expression discriminates porcine NK cells with different functional properties. Eur J Immunol. 2012; 42(5):1261-1271

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