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Selected Publication:

Type of publication: PhD Thesis
Type of document:

Year: 2013

Authors: Reutner, Katharina

Title: Identification of Swine Workshop Cluster 2 as porcine CD27 and its role in the discrimination of functionally distinct T helper cells.

Source: PhD-Arbeit, Vet. Med. Univ. Wien, pp. 62.


Saalmüller Armin

Summerfield Artur

Vetmed Research Units:
Institute of Immunology

Graduation date: 06.12.13

At the “1st international swine cluster of differentiation workshop” in 1992 the so called swine workshop cluster 2 (SWC2) was defined, comprising two monoclonal antibodies (mAbs) that recognized a cell surface molecule with a molecular weight of approximately 50 kDa. However, the orthologous human cluster of differentiation (CD) molecule as well as the functional relevance of SWC2 remained unknown. Hence, the aims of this PhD project were the molecular identification of SWC2 and studies on the expression of SWC2 on lymphocyte subsets with a focus on the functional properties of SWC2-defined T helper cells. Furthermore, it was hypothesized that SWC2-defined T helper cells play a role in the acquired immune response against viral infections such as porcine reproductive and respiratory syndrome virus (PRRSV) and swine influenza A virus (FLUAVsw).

Publication(s) resulting from University thesis:

Reutner, K; Leitner, J; Müllebner, A; Ladinig, A; Essler, SE; Duvigneau, JC; Ritzmann, M; Steinberger, P; Saalmüller, A; Gerner, W (2013): CD27 expression discriminates porcine T helper cells with functionally distinct properties. Vet Res. 2013; 44:18
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Reutner, K; Leitner, J; Essler, SE; Witter, K; Patzl, M; Steinberger, P; Saalmüller, A; Gerner, W (2012): Porcine CD27: identification, expression and functional aspects in lymphocyte subsets in swine. Dev Comp Immunol. 2012; 38(2):321-331

Leitner, J; Reutner, K; Essler, SE; Popow, I; Gerner, W; Steinberger, P; Saalmüller, A (2012): Porcine SWC1 is CD52--final determination by the use of a retroviral cDNA expression library. Vet Immunol Immunopathol. 2012; 146(1):27-34
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