At the 1st international swine cluster of differentiation workshop in 1992 the so
called swine workshop cluster 2 (SWC2) was defined, comprising two monoclonal antibodies
(mAbs) that recognized a cell surface molecule with a molecular weight of approximately 50
kDa. However, the orthologous human cluster of differentiation (CD) molecule as well as the
functional relevance of SWC2 remained unknown. Hence, the aims of this PhD project were
the molecular identification of SWC2 and studies on the expression of SWC2 on lymphocyte
subsets with a focus on the functional properties of SWC2-defined T helper cells.
Furthermore, it was hypothesized that SWC2-defined T helper cells play a role in the acquired
immune response against viral infections such as porcine reproductive and respiratory
syndrome virus (PRRSV) and swine influenza A virus (FLUAVsw).