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Selected Publication:

Publication type: Journal Article
Document type: Case Report

Year: 2011

Author(s): Zebeli, Q; Ametaj, BN

Title: Peripartal inflammatory condition in a Holstein cow affected by downer cow syndrome: a retrospective case report.

Other title: Veränderungen von Parametern des Immunsystems im Plasma einer Kuh mit dem Downer-Cow-Syndrom: eine retrospektive Fallstudie

Source: Wien Tierarztl Monat (98), 5-6 126-132.

Authors Vetmeduni Vienna:

Zebeli Qendrim

Vetmed Research Units
Institute of Animal Nutrition and Functional Plant Compounds


Abstract:
Longitudinal changes in the variables of innate immunity, metabolites, and minerals were measured during the periparturient period in the plasma of a 7year-old Holstein cow incidentally affected by downer cow syndrome (DCS) postpartum, and these data were compared with results of 7 clinically healthy Holstein cows, which served as controls. During the prepartum period the DCS-cow demonstrated a dramatic increase of plasma lipopolysaccharide(LPS)-binding protein compared with the controls and a dramatic rise in the concentrations of non-esterified fatty acids, beta-hydroxybutyrate, and zinc as well as lower anti-LPS immunoglobulin G and cholesterol in the plasma. In conclusion, this retrospective case report suggests that the LPS-induced inflammation and the metabolic perturbations before parturition may facilitate the development, or aggravate the outcome, of downer cow syndrome postpartum.

Abstract:

Keywords:
downer cow syndrome, acute phase response, plasma calcium, metabolism.


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