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Selected Publication:

Publication type: Journal Article
Document type: Full Paper

Year: 1992

Author(s): Leidinger, E; Loupal, G; Gutleb, R; Miller, I; Chizzola, R

Title: Toxic Effects After Immunization Against The Pyrrolizidin Alkaloid Retrorsin.

Source: Deut Tierarztl Woch. 1992; 99(8): 332-335.

Authors Vetmeduni Vienna:

Chizzola Remigius
Loupal Gerhard
Miller Ingrid

Vetmed Research Units
Institute for Medical Biochemistry
Institute of Animal Nutrition and Functional Plant Compounds
Institute of Pathology

Six rabbits were immunized against the pyrrolizidine alkaloid retrorsin, conjugated to bovine serum albumin. Seven i. v. inoculations were distributed over a period of half a year. The total antigen dose differed between animals. Towards the end of the experiment all animals (except 2 receiving the lowest antigen dose) suffered from apathy, anorexia and loss of body weight. Pathologically these symptoms correlated well with liver cirrhosis, gradually dependent on the total antigen dose. Blood-chemical parameters were disparate and contradictory.

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