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Publication type: Doctoral Thesis

Year: 2011

Author(s): Miljkovic, Vladan

Title: Beurteilung der Wirksamkeit von Aivlosin (Acetylisovaleryltylosintartrat) in zwei unterschiedlichen Dosierungen gegen Infektion mit Lawsonia intracellularis.

Other title: Assessing the efficasy of Aivlosin (Acetylisovaleryltylosin Tartrat) in two different dosages against infection with Lawsonia intracellularis

Source: Dissertation, Vet. Med. Univ. Wien, pp. 96.


Ladinig Andrea
Ritzmann Mathias

Ritzmann Mathias
Weissenböck Herbert

Vetmed Research Units:
University Clinic for Swine

Graduation date: 08.06.11

The Porcine Proliferative Enteropathy still describes one of the most important intestinal diseases in the pig production worldwide that causes high economical losses. In this study the efficacy of Aivlosin® to control PPE was tested in two different doses on a farm with natural infection with Lawsonia intracellularis. After weaning, the animals were allocated to one of three different groups: one control group (0 %) and two treated groups. One treated group received Aivlosin® by feed over a period of 14 days in a concentration of 2.125 mg/kg wt (50 % group) and the other group received 4.25 mg/kg wt (100 %) over a period of ten days. All animals were weighed at the beginning of the trial (5th week of life), at the end of the nursery (13th week of life) as well as at the end of the fattening period (24th week of life). Faecal samples were taken from 17 % of the animals every other week. Those samples were analysed by triplex PCR to detect genome fragments from L. intracellularis, B. hyodysenteriae and B. pilosicoli. In case of a positive result for L. intracellularis, the individual sample was further analysed by qPCR to quantify the bacteria. The body weight results from both treated groups showed significantly higher values compared to those from the control group at the end of the nursery as well as at the end of the fattening period. There were no significant differences between the two treated groups. When weighing in the 13th week of life, the daily weight gain of the 100 % group was significant higher compared to that of the 0 % group. The calculation of the feed conversion rate over the nursery period showed significant differences between the 100 % group and the other two groups. In addition to these parameters, the uniformity of the pigs before slaughter was evaluated. Results of this calculation demonstrate significant differences in favour of the finishing pigs from the 100 % group. The faecal shedding of the pathogen was detected from the 5th to the 21st week of life in the 0 % group, from the 7th to the 21st week of life in the 50 % group, and from the 7th to the 17th week of life in the 100 % group. The results of this study demonstrate a positive effect of Aivlosin® in the concentration of 2.215 mg/kg wt over a period of 14 days to control of PPE. However, the efficacy of that dose could not reach the level of the treatment with 4.25 mg/kg wt for ten days in all fields.

pig / PPE / Aivlosin

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