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Selected Publication:

Type of publication: Journal Article
Type of document: Full Paper

Year: 2008

Authors: Nunes, MD; Neumeier, H; Schlötterer, C

Title: Contrasting patterns of natural variation in global Drosophila melanogaster populations.

Source: Mol Ecol. 2008; 17(20):4470-4479

Authors Vetmeduni Vienna:

Schlötterer Christian

Vetmed Research Units
Institute of Population Genetics

Project(s): Local selective sweeps in Drosophila melanogaster

Despite the popularity of Drosophila melanogaster in functional and evolutionary genetics, the global pattern of natural variation has not yet been comprehensively described in this species. For the first time, we report a combined survey using neutral microsatellites and mitochondrial sequence variation jointly. Thirty-five populations originating from five continents were compared. In agreement with previous microsatellite studies, sub-Saharan African populations were the most variable ones. Consistent with previous reports of a single "out of Africa" habitat expansion, we found that non-African populations contained a subset of the African alleles. The pattern of variation detected for the mitochondrial sequences differed substantially. The most divergent haplotypes were detected in the Mediterranean region while Africa harboured most haplotypes, which were all closely related. In the light of the well-established African origin of D. melanogaster, our results cast severe doubts about the suitability of mtDNA for biogeographic inference in this model organism.

Keywords Pubmed: Alleles
Bayes Theorem
Cluster Analysis
DNA, Mitochondrial/genetics
Drosophila melanogaster/genetics*
Evolution, Molecular*
Genes, Insect
Genes, Mitochondrial
Genetic Variation*
Genetics, Population*
Microsatellite Repeats
Species Specificity

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