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Publication type: Journal Article
Document type: Full Paper

Year: 2018

Author(s): Newman, MA; Petri, RM; GrĂ¼ll, D; Zebeli, Q; Metzler-Zebeli, BU

Title: Transglycosylated Starch Modulates the Gut Microbiome and Expression of Genes Related to Lipid Synthesis in Liver and Adipose Tissue of Pigs.

Source: Front Microbiol. 2018; 9:224



Authors Vetmeduni Vienna:

Metzler-Zebeli Barbara
Newman Monica
Petri Renee
Zebeli Qendrim

Vetmed Research Units
Institute of Animal Nutrition and Functional Plant Compounds


Project(s): Establishment of a reliable in vivo model for the classification of the health-promoting effects of carbohydrates


Abstract:
Dietary inclusion of resistant starches can promote host health through modulation of the gastrointestinal microbiota, short-chain fatty acid (SCFA) profiles, and lipid metabolism. This study investigated the impact of a transglycosylated cornstarch (TGS) on gastric, ileal, cecal, proximal-colonic, and mid-colonic bacterial community profiles and fermentation metabolites using a growing pig model. It additionally evaluated the effect of TGS on the expression of host genes related to glucose and SCFA absorption, incretins, and satiety in the gut as well as host genes related to lipid metabolism in hepatic and adipose tissue. Sixteen growing pigs (4 months of age) were fed either a TGS or control (CON) diet for 11 days. Bacterial profiles were determined via Illumina MiSeq sequencing of the V3-5 region of the 16S rRNA gene, whereas SCFA and gene expression were measured using gas chromatography and reverse transcription-quantitative PCR.


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