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Type of publication: Journal Article
Type of document: Full Paper

Year: 2018

Authors: Pashkovskaya, AA; Vazdar, M; Zimmermann, L; Jovanovic, O; Pohl, P; Pohl, EE

Title: Mechanism of Long-Chain Free Fatty Acid Protonation at the Membrane-Water Interface.

Source: Biophys J. 2018; 114(9):2142-2151

Authors Vetmeduni Vienna:

Jovanovic Olga
Pashkovskaya Alina
Pohl Elena
Zimmermann Lars

Vetmed Research Units
Institute of Physiology, Pathohysiology and Biophysics, Unit of Physiology and Biophysics

Project(s): Mechanism of nucleotide-mediated inhibition of mitochondrial uncoupling proteins

Long-chain free fatty acids (FFAs) play an important role in several physiological and pathological processes such as lipid fusion, adjustments of membrane permeability and fluidity, and the regulation of enzyme and protein activities. FFA-facilitated membrane proton transport (flip-flop) and FFA-dependent proton transport by membrane proteins (e.g., mitochondrial uncoupling proteins) are governed by the difference between FFA"s intrinsic pK

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