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Type of publication: Journal Article
Type of document: Review Article

Year: 2019

Authors: Ashfaq, H; Soliman, H; Saleh, M; El-Matbouli, M

Title: CD4: a vital player in the teleost fish immune system.

Source: Vet Res. 2019; 50(1):1

Authors Vetmeduni Vienna:

Ashfaq Hassan
El-Matbouli Mansour
Saleh Mona
Soliman Hatem

Vetmed Research Units
University Clinic for Poultry and Fish Medicine, Clinical Unit of Fish Medicine

Project(s): The role of SOCS Proteins in salmonid whirling disease

CD4 is a nonpolymorphic transmembrane glycoprotein molecule that is expressed on the surface of T-helper cells and plays an essential role in the immune response. It functions as a coreceptor with the T-cell receptor by binding to major histocompatibility complex class II on the surface of dendritic cells that present antigens. CD4+ T cells hold a key position in coordinating the immune system through production of several cytokines after activation and differentiation. The CD4+ T helper subtypes (T-helper 1, T-helper 2, T-helper 17, T-helper 9, and regulatory-T cells) perform different immune functions subsequent to their differentiation from the naive T cells. Different types of CD4+ T cells require different cytokines such as drivers and effectors, as well as master transcription factors for their activation. Fish cells that express CD4-related genes are activated in the presence of a pathogen and release cytokines against the pathogen. This review highlights the types of CD4+ T cells in fish and describes their direct role in cell-mediated and humoral immunity for protection against the intracellular bacterial as well as viral infections in fish.

Keywords Pubmed: Animals
Bacterial Infectionsimmunologyveterinary
CD4-Positive T-Lymphocytesimmunology
Fish Diseasesimmunology
Immunity, Cellular
Immunity, Humoral
Virus Diseasesimmunologyveterinary

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