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Publication type: Journal Article
Document type: Full Paper

Year: 2017

Author(s): Lukasch, B; Westerdahl, H; Strandh, M; Winkler, H; Moodley, Y; Knauer, F; Hoi, H

Title: Genes of the major histocompatibility complex highlight interactions of the innate and adaptive immune system.

Source: PeerJ. 2017; 5:e3679

Authors Vetmeduni Vienna:

Hoi Herbert,
Knauer Felix,
Moodley Yoshan,
Winkler Hans,

Vetmed Research Units
Conservation Medicine, Research Institute of Wildlife Ecology
Konrad Lorenz Institute of Ethology,

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Project(s): Costs and benefit of genetic mate choice

A well-functioning immune defence is crucial for fitness, but our knowledge about the immune system and its complex interactions is still limited. Major histocompatibility complex (MHC) molecules are involved in T-cell mediated adaptive immune responses, but MHC is also highly upregulated during the initial innate immune response. The aim of our study was therefore to determine to what extent the highly polymorphic MHC is involved in interactions of the innate and adaptive immune defence and if specific functional MHC alleles (FA) or heterozygosity at the MHC are more important.

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