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Publication type: Journal Article
Document type: Full Paper

Year: 2019

Author(s): Seiffert, I; van Dijk, RM; Koska, I; Di Liberto, V; Möller, C; Palme, R; Hellweg, R; Potschka, H

Title: Toward evidence-based severity assessment in rat models with repeated seizures: III. Electrical post-status epilepticus model.

Source: Epilepsia. 2019; 60(8):1539-1551

Authors Vetmeduni Vienna:

Palme Rupert

Vetmed Research Units
Institute of Physiology, Pathohysiology and Biophysics, Unit of Physiology, Pathophysiology, and Experimental Endocrinology

Ethical approval of experiments in chronic epilepsy models requires a careful balancing of the expected gain-in-knowledge with the level of distress. Thus recommendations for evidence-based severity assessment and classification are urgently needed for preclinical epilepsy research.

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