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Publication type: Journal Article
Document type: Full Paper

Year: 2019

Author(s): Shikov, AN; Pozharitskaya, ON; Faustova, NM; Kosman, VM; Makarov, VG; Razzazi-Fazeli, E; Novak, J

Title: Pharmacokinetic Study of Bioactive Glycopeptide from Strongylocentrotus droebachiensis After Intranasal Administration to Rats Using Biomarker Approach.

Source: Mar Drugs. 2019; 17(10):577


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VetCore (Proteomics);

Authors Vetmeduni Vienna:

Novak Johannes
Razzazi-Fazeli Ebrahim

Vetmed Research Units
Institute of Animal Nutrition and Functional Plant Compounds
VetCore


Abstract:
A glycopeptide fraction (GPF) from internal organs of green sea urchins ( Strongylocentrotus droebachiensis Müller, Strongylocentrotidae) has been reported to be an effective bronchitis treatment. In this study, we evaluated the pharmacokinetic and tissue distribution of GPF, following single and repeated intranasal (i/n) administration over the course of seven days in rats. The method measuring lactate dehydrogenase as biomarker was used to analyse the plasma and tissue concentrations of GPF. GPF appears in the plasma 15 min after single i/n administration (100 µg/kg) and reaches its maximum at 45 min. The area under the curve (AUC)


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