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Selected Publication:

Type of publication: Journal Article
Type of document: Case Report

Year: 2020

Authors: Eberspächer-Schweda, MC; Schmitt, K; Handschuh, S; Fuchs-Baumgartinger, A; Reiter, AM

Title: Diagnostic Yield of Micro-Computed Tomography (micro-CT) Versus Histopathology of a Canine Oral Fibrosarcoma.

Source: J Vet Dent. 2020; 37(1):14-21

Authors Vetmeduni Vienna:

Eberspächer-Schweda Matthias
Fuchs-Baumgartinger Andrea
Handschuh Stephan

Vetmed Research Units
University Clinic for Small Animals, Clinical Unit of Small Animal Surgery
Institute of Pathology

Micro-computed tomography (micro-CT) imaging currently gains increased interest in human as well as veterinary medicine. The ability to image 3-dimensional (3D) biopsy specimens nondestructively down to 1 µm spatial resolution makes it a promising tool for microscopic tissue evaluation in addition to histopathology. Visualizing tumor margins and calculating tumor load on 3D reconstructions may also enhance oncological therapies. The objective of this study was to describe the workflow from tumor resection to histopathological diagnosis, using both routine hematoxylin-eosin (HE)-stained sections and micro-CT tomograms on a stage II oral fibrosarcoma in a 7-year-old Hovawart dog. The maxillectomy specimen was fixed with formalin and stained with an X-ray dense soft tissue contrast agent. Micro-CT imaging was done using an ex vivo specimen micro-CT device. Tumor margins could not be exactly determined on micro-CT tomograms due to limited image resolution and contrast. Histopathology was performed after washing out the contrast agent. It showed neoplastic cells infiltrating the surrounding tissue further than assumed from micro-CT images. A total tumor volume of 10.3 cm

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