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Selected Publication:

Type of publication: Doctoral Thesis
Type of document:

Year: 2011

Authors: Orozco ter Wengel, Pablo Andres

Title: Population Genetics of Drosophila.

Other title: Drosophila Populationsgenetik

Source: Dissertation, Vet. Med. Univ. Wien, pp. 233.


Authors Vetmeduni Vienna:

Orozco ter Wengel Pablo

Advisor(s):
Schlötterer Christian

Reviewer(s):
Müller Mathias

Vetmed Research Units:
Institute of Population Genetics


Graduation date: 14.04.11


Abstract:
The studies presented in this thesis deal with the inference of the evolutionary history of D. melanogaster and its siblings species using molecular markers, and with the development of the bioinformatic tools required for the analysis of NGS pooled DNA data for population genomic studies. Chapter 2 focuses on the effect of genealogical lineage sorting on the inference of population structure with Bayesian methods like BAPS (Corander & Marttinen 2006) or STRUCTURE (Pritchard et al. 2000). Here is shown that it is desirable that when describing population structure, researchers not only focus on the statistical support for the inferred clustering solution but also assess whether their result are robust to marker sampling variation. Chapter 3 deals with the study of hybridization between D. simulans and D. mauritiana. The main result of this study is the determinatino of two new events of mitochondrial introgression between these species. It is also shown that some nuclear markers seems to carry information about these histociral hybridization events implying hybridization may be a more common evolutionary event than previously thought. Chapter 4 deals with the implementation of bioinformatic tools for the analysis of NGS data of pooled DNA samples. The introduced toolbox will extensively serve the community as sequencing pools of DNA becomes more frequent. Furthermore, it is expected that the implementation of the quality measurements described in this study by the community will render future published data of a higher quality and reliability.

Keywords:
Drosophila / Evolution / Hybridization / Microsatellites / Next Generation Sequencing / Population structure


Publication(s) resulting from University thesis:

Orozco-terWengel, P; Corander, J; Schlötterer, C (2011): Genealogical lineage sorting leads to significant, but incorrect Bayesian multilocus inference of population structure. Mol Ecol. 2011; 20(6):1108-1121
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Kofler, R; Orozco-terWengel, P; De Maio, N; Pandey, RV; Nolte, V; Futschik, A; Kosiol, C; Schlötterer, C (2011): PoPoolation: a toolbox for population genetic analysis of next generation sequencing data from pooled individuals. PLoS One. 2011; 6(1):e15925
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Nunes, MD; Wengel, PO; Kreissl, M; Schlötterer, C (2010): Multiple hybridization events between Drosophila simulans and Drosophila mauritiana are supported by mtDNA introgression. Mol Ecol. 2010; 19(21):4695-4707
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