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Type of publication: Diploma Thesis
Type of document:

Year: 2011

Authors: Brumme, Stephanie

Title: Ciklosporintherapie bei "Meningoencephalitis of Unknow Origin" des Hundes.

Other title: Cyclosporine therapy in Meningoencepalitis of Unknown Origin in dogs

Source: Diplomarbeit, Vet. Med. Univ. Wien, pp. 44.


Advisor(s):

Pakozdy Akos
Thalhammer Johann

Reviewer(s):
Loupal Gerhard

Vetmed Research Units:
University Clinic for Small Animals, Clinical Unit of Internal Medicine Small Animals


Graduation date: 02.09.11


Abstract:
Granulomatous meningoencephalomyelitis (GME), necrotizing meningoencephalitis (NME) and necrotizing leukoencephalitis (NLE) are common diseases of the CNS in dogs. Many of the affected animals die after a short period of time or get euthanized. Each disease has its own histopathologic characteristics. However the similarity seems to be the abnormal immunological response directed against the CNS. It is very difficult to make a diagnosis in the alive animal. Therefore ante martern the terminology m􀈡ningoencephalitis of unknown origin (MUO) is rather used. Diversity shows up not just within the presumed etiologies but also within the therapeutic options. The standard treatment with corticosteroids is often insufficient. A possible alternative is the potent immunosuppressive drug Ciclosporin. Based on our comparative study on 1 6 dogs treated with a combined therapy of ciclosporin and corticosteroids and 1 2 dogs with a sole corticoid therapy, an additioned benefit of Ciclosprin was noticed. Dogs treated with the combined therapy had a higher remission rate and Ionger survival time. Side effects during therapy were rare and became apparent in gastrointestinal and dermatological disorders.


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