Granulomatous meningoencephalomyelitis (GME), necrotizing meningoencephalitis
(NME) and necrotizing leukoencephalitis (NLE) are common diseases
of the CNS in dogs. Many of the affected animals die after a short period of time
or get euthanized. Each disease has its own histopathologic characteristics.
However the similarity seems to be the abnormal immunological response
directed against the CNS. It is very difficult to make a diagnosis in the alive animal.
Therefore ante martern the terminology mningoencephalitis of unknown
origin (MUO) is rather used. Diversity shows up not just within the presumed
etiologies but also within the therapeutic options. The standard treatment with
corticosteroids is often insufficient. A possible alternative is the potent immunosuppressive
Based on our comparative study on 1 6 dogs treated with a combined therapy of
ciclosporin and corticosteroids and 1 2 dogs with a sole corticoid therapy, an
additioned benefit of Ciclosprin was noticed. Dogs treated with the combined
therapy had a higher remission rate and Ionger survival time. Side effects during
therapy were rare and became apparent in gastrointestinal and dermatological