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Type of publication: Doctoral Thesis
Type of document:

Year: 2013

Authors: Wandling, Isabelle

Title: Coenzym Q10- ein Faktor bei Herzerkrankungen von Hunden.

Other title: Coenzyme Q10- a factor in heart disease of dogs

Source: Dissertation, Vet. Med. Univ. Wien, pp. 83.


Advisor(s):

Thalhammer Johann

Reviewer(s):
Gille Lars

Vetmed Research Units:
University Clinic for Small Animals, Clinical Unit of Internal Medicine Small Animals


Graduation date: 11.06.13


Abstract:
Congestive heart failure is one of the most common causes of death in dogs. In human medicine, lower coenzyme Q10 concentrations have been made responsible to be a cause or the consequence of heart failure for a long time. The aim of this study coenzyme Q10- a factor in heart disease of dogs was to establish coenzyme Q10 reference levels for healthy dogs and to compare the results between healthy dogs and those who suffer from different stages of cardiac failure or other systemic diseases. Furthermore if there is a difference in coenzyme Q10 concentrations concerning age, sex, heart failure stages, heart size and fractional shortening. For this purpose 86 dogs were examined in the time interval of 2009 to 2010. The dogs were classified into one of the following groups: "healthy", "cardiac failure patients", "dogs with a different severe illness" and "dogs with oral coenzyme Q10 supplementation". Based on the history and the clinical examination of the cardiovasculary system the patients with cardiac failure were divided into the following four stages "NYHA I", "NYHA II", "NYHA III" and NYHA "IV". Therefore the New York Heart Association scheme from the human medicine was used in modified form for dogs (NEW YORK HEART ASSOCIATION, 1964). The classification of stages was made based on physical working capacity.


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