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Publication type: Journal Article
Document type: Full Paper

Year: 2006

Author(s): Grassi, P; UrĂ­as Reyes, TS; Sosa, S; Tubaro, A; Hofer, O; Zitterl-Eglseer, K

Title: Anti-inflammatory activity of two diterpenes of Hyptis suaveolens from El Salvador.

Source: Z Naturforsch C. 2006; 61(3-4):165-170

Authors Vetmeduni Vienna:

Grassi Paolo
Zitterl-Eglseer Karin

Vetmed Research Units
Institute of Animal Nutrition and Functional Plant Compounds

Project(s): Phytochemical investigations of Hyptis suaveolens

Separation and isolation of the two main compounds suaveolol and methyl suaveolate from leaves of chichinguaste (Hyptis suaveolens Poit., Lamiaceae) could be achieved by means of repeated column chromatography and repeated preparative thin layer chromatography. Their chemical structures were approved by MS, 1H NMR, 13C NMR and 2D-NMR experiments. The anti-inflammatory activity of the two compounds was tested for the first time as inhibition of croton oil-induced dermatitis of the mouse ear. Suaveolol and methyl suaveolate showed nearly the same dose-dependent topical anti-inflammatory activity, only two to three times lower than that of the reference drug indomethacin. The anti-inflammatory properties of these compounds could contribute to the antiphlogistic activity of extracts of Hyptis species and confirm the rational use of Hyptis suaveolens extracts in dermatological diseases.

Keywords Pubmed: Animals
Anti-Inflammatory Agents, Non-Steroidal/isolation & purification*
Chromatography, Thin Layer
Dermatitis/drug therapy
Diterpenes/isolation & purification*
El Salvador
Magnetic Resonance Spectroscopy
Mass Spectrometry

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